Pentobarbital will minimize the level or impact of buprenorphine buccal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. pentobarbital will reduce the level or impact of buprenorphine subdermal implant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Observe patients presently on buprenorphine subdermal implant wh... https://edwardj414cug7.therainblog.com/profile