Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals from the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have identified recurrent mutations in genes regulating tumor mobile-microenvironment interactions, whic... https://adolfq888mfx9.levitra-wiki.com/user